Topmax – Topiramate – Wikipedia

Topmax

Topamax is a prescription medication sold under the generic name topiramate. It is most commonly prescribed to treat seizures and for prevention of migraine headaches. It also seems to help with weight loss. Learn more about how Topamax …

Interactions[ edit ] Topiramate has many drug-drug interactions. Topiramate itself is a weak inhibitor of CYP2C19 and induces CYP3A4 ; a decrease in plasma levels of estrogens and digoxin has been noted during topiramate therapy.

As topiramate may result in acidosis other treatments that also do so may worsen this effect. Topiramate is quickly absorbed after oral use.

The remainder is extensively metabolized by hydroxylation , hydrolysis , and glucuronidation. Several cellular targets have been proposed to be relevant to the therapeutic activity of topiramate.

There is evidence that topiramate may alter the activity of its targets by modifying their phosphorylation state instead of by a direct action.

Effects on specific GABA-A receptor isoforms could also contribute to the antiseizure activity of the drug. Topiramate selectively inhibits cytosolic type II and membrane associated type IV forms of carbonic anhydrase.

The action on carbonic anhydrase isoenzymes may contribute to the drug’s side-effects, including its propensity to cause metabolic acidosis and calcium phosphate kidney stones. Topiramate inhibits maximal electroshock and pentylenetetrazol -induced seizures as well as partial and secondarily generalized tonic-clonic seizures in the kindling model, findings predictive of a broad spectrum of activities clinically.

Its action on mitochondrial permeability transition pores has been proposed as a mechanism. Maryanoff and Joseph F. Gardocki during their research work at McNeil Pharmaceuticals.

Uses and Side Effects of Topamax – Verywell Health

Topamax is a prescription medication sold under the generic name topiramate. It is most commonly prescribed to treat seizures and for prevention of migraine headaches. It also seems to help with weight loss. Learn more about how Topamax …

https://www.verywellhealth.com/what-is-topamax-3015258

Topamax: Uses, Dosage, Side Effects – Drugs.com

Jan 14, 2021 · Topamax (topiramate) was originally FDA-approved as a seizure medicine, also called an anticonvulsant. Topiramate is used to treat seizures in adults and children who are at least 2 years old. Topamax is also used to prevent migraine headaches in adults and …Estimated Reading Time: 7 mins

https://www.drugs.com/topamax.html

Topamax: Side effects, uses, dosage, withdrawal, and more

Topmax

Nov 09, 2020 · Topamax is a brand-name drug that contains the active drug topiramate. This active drug is also available as a generic medication. A generic drug is …Estimated Reading Time: 8 mins

https://www.medicalnewstoday.com/articles/topamax

Topamax: Side effects, uses, dosage, withdrawal, and more

Nov 09, 2020 · Topamax is a brand-name drug that contains the active drug topiramate.This active drug is also available as a generic medication. A generic drug is an exact copy of the active drug in a brand …

https://www.medicalnewstoday.com/articles/topamax

Topamax (Topiramate) – Side Effects, Interactions, Uses …

Nov 24, 2020 · Find everything you need to know about Topamax (Topiramate), including what it is used for, warnings, reviews, side effects, and interactions. Learn more about Topamax (Topiramate) at …

https://www.everydayhealth.com/drugs/topamax

topiramate, Topamax for Migraine Side Effects & Dosage

Topiramate (Topomax, Qudexy XR, Topamax Sprinkle, Topiragen, Trokendi XR) is a drug prescribed for the prevention of the seizures of epilepsy and prevention of migraine headaches. Side effects, drug …

https://www.medicinenet.com/topiramate/article.htm

TOPAMAX® Eligible Patients Can Pay $4 TOPAMAX …

Topmax

TOPAMAX® may cause eye problems. Serious eye problems include: Any sudden decrease in vision with or without eye pain and redness. A blockage of fluid in the eye causing increased pressure in the eye (secondary angle closure glaucoma).

https://www.topamax.com/

Topamax (Topiramate) – Side Effects, Interactions, Uses …

Nov 24, 2020 · Topiramate is a medicine used to treat certain types of seizures. This drug is also sometimes given to help prevent migraine headaches from occurring. Topiramate is in a class of medicines called…3/5

https://www.everydayhealth.com/drugs/topamax

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